{"product_id":"biolegend-681102","title":"Biolegend, 681102, Purified anti-FGF-19 Antibody, 100μg","description":"\u003cp\u003eFGF-19 belongs to a subfamily of the fibroblast growth factors (FGFs) called endocrine FGFs, which consists of FGF-19, FGF-21, and FGF-23. Unlike other subfamily of FGFs, FGF-19 has a low binding affinity to heparin sulfate and functions as a circulating hormone with effects on distant tissues. FGF-19 has reduced binding affinity to the FGF receptors and the interaction requires two necessary cofactors that are α-Klotho and β-Klotho. In the ileum, FGF-19 expression is initiated by bile acids-induced activation of farnesoid X receptor (FXR). In response to bile acid stimulation, FGF-19 is secreted and enters the portal venous circulation, which subsequently down-regulates hepatic bile acid synthesis through repression of the CYP7A1 gene encoding cholesterol 7-alpha-monooxygenase. The impaired regulation of bile acids by FGF-19 leads to bile acid diarrhea also known as idiopathic bile acid malabsorption. FGF-19 has also been demonstrated to regulate carbohydrate and lipid metabolism.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial human FGF-19 recombinant protein (25-216 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2566443 (BioLegend Cat. No. 681102)\u003cbr\u003e\nStructure: Growth factor. 216 amino acids with a predicted molecular weight of 24 kD.\u003cbr\u003e\nDistribution: Secreted.\u003cbr\u003e\nFunction: FGF-19 functions as a hormone, regulating homeostasis of bile acid, glucose, lipids, phosphate, and vitamin D.\u003cbr\u003e\nInteraction: Interacts with heparian, α-Klotho, and β-Klotho.\u003cbr\u003e\nLigand\/Receptor: FGFR1, FGFR2, FGFR3, and FGFR4.\u003cbr\u003e\nBiology Area: Cell Biology\u003cbr\u003e\nMolecular Family: Growth Factors, Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Xie MH, et al. 1999. Cytokine 11:729.2. Harmer NJ, et al. 2004. Biochemistry 43:629.3. Goetz R, et al. 2007. Mol. Cell Biol. 27:3417.4. Wu X, et al. 2008. J. Biol. Chem. 283:33304.5. Song KH, et al. 2009. Hepatology 49:297.6. Turner N, et al. 2010. Nat. Rev. Cancer 10:116.\u003cbr\u003e\nGene ID: 9965\u003cbr\u003e\nUniProt: View information about FGF-19 on UniProt.org\u003cbr\u003e\nClone: 13D9C80\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fibroblast growth factor 19\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864329343145,"sku":"681102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-681102","provider":"Iright","version":"1.0","type":"link"}