{"product_id":"biolegend-688602","title":"Biolegend, 688602, Purified anti-CaMKII Antibody, 100μg","description":"\u003cp\u003eThe Ca2 + \/calmodulin (CaM)-dependent protein kinases (CaMKs) are multifunctional serine\/threonine kinases whose activity are regulated through Ca2 + signaling. CaMKII is expressed as a multimeric protein, which typically is comprised of 12 subunits in physiological conditions. CaMKII is an important member of the calcium\/calmodulin-activated protein kinase family. It phosphorylates nearly 40 different proteins, including enzymes, ion channels, kinases, and transcription factors. CaMKII plays critical roles in neural synaptic stimulation and T cell receptor signaling. Recent studies suggested that high levels of CaMKII is also expressed in variety of cancers. It regulates proliferation, differentiation and survival of cancer cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: 50% pure type II CaM kinase, purified through Calmodulin-Sepharose step.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-F - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg\/ml. For immunohistochemical staining on frozen tisse sections, a concentration range of 2.0 - 10 μg\/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Erondu NE, et al. 1985. J. Neurosci. 5:3270.\u003cbr\u003e\nRRID: AB_2617027 (BioLegend Cat. No. 688602)\u003cbr\u003e\nStructure: 478 amino acids with a predicted molecular weight of 50 kD.\u003cbr\u003e\nDistribution: Synapse and cytosol.\u003cbr\u003e\nFunction: A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release; member of the NMDAR signaling complex in excitatory synapses it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.\u003cbr\u003e\nInteraction: BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase, TCRs\u003cbr\u003e\nAntigen References: 1. Hook SS, et al. 2001. Annu. Rev. Pharmacol. Toxicol. 41:471. 2. Hoelz A, et al. 2003. Mol. Cell 11:1241. 3. Lisman J, et al. 2012. Nat. Rev. Neurosci. 13:169. 4. Barria A, et al. 1997. Science 276:2042. 5. Hughes K, et al. 2001. J. Biol. Chem. 276:36008. 6. Wang YY, et al. 2015. Oncotarget. 6:11725.\u003cbr\u003e\nGene ID: 815\u003cbr\u003e\nUniProt: View information about CaMKII on UniProt.org\u003cbr\u003e\nClone: 6G9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CAMK2, CaM kinase II, Calcium\/calmodulin-dependent protein kinase type II subunit alpha\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862479851689,"sku":"688602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-688602","provider":"Iright","version":"1.0","type":"link"}