{"product_id":"biolegend-690702","title":"Biolegend, 690702, Purified anti-SH2D1A (SAP) Antibody, 100μg","description":"\u003cp\u003eSH2D1A, also known as SAP, is a small adaptor protein which plays a major role in the bidirectional stimulation of T and B cells. SH2D1A is predominantly expressed in T cells and NK cells, and functions to regulate signal transduction pathways downstream of the SLAM family of surface receptors. The SH2D1A gene is frequently mutated in patients with X-linked lymphoproliferative disease. Malfunction of the SLAM-SAP pathway results in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Full length purified human SH2D1A.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2629824 (BioLegend Cat. No. 690702)\u003cbr\u003e\nStructure: 128 amino acids with a characteristic of SH2 domain. The predicted molecular weight is approximately 14kD.\u003cbr\u003e\nDistribution: T cells, NK cells and monocytes.\u003cbr\u003e\nFunction: Stimulation of T and B cells.\u003cbr\u003e\nInteraction: SLAM family, SH2D1B, and FYN.\u003cbr\u003e\nLigand\/Receptor: SLAM family; SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7.\u003cbr\u003e\nCell Type: T cells, NK cells, Monocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nAntigen References: 1. Tangye SG. 2014. J. Clin. Immunol. 34:772.2. Yang X, et al. 2012. Pediatr. Int. 54:447.3. Ma CS, Deenick EK. 2011. Ann. N Y Acad. Sci. 1217:32-44.4. Detre C, et al. 2010. Semin. Immunopathol. 32:157.5. Vilar ML, et al. 2011. Braz. J. Med. Biol. Res. 44:276.\u003cbr\u003e\nGene ID: 4068\u003cbr\u003e\nUniProt: View information about SH2D1A on UniProt.org\u003cbr\u003e\nClone: 1A9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SH2 Domain Containing 1A, SAP, T-Cell Signal Transduction Molecule SAP, SLAM-Associated Protein, T Cell Signal Transduction Molecule SAP, MTCP1, XLPD\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860839354537,"sku":"690702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-690702","provider":"Iright","version":"1.0","type":"link"}