{"product_id":"biolegend-691002","title":"Biolegend, 691002, Purified anti-P2RX7 Antibody, 100μg","description":"\u003cp\u003eP2X purinoceptor 7 (P2RX7) is a member of the purinergic receptor P2X family. P2 purinergic receptors are cell surface receptors that are involved in proliferation of neural stem cells and have been implicated in learning, memory, and sleep. P2X receptors are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP binding. Functional P2X receptors are homo- or heterotrimeric complex composed of the P2X family members. P2RX7 functions as a ligand-gated cation channel and is responsible for synaptic transmission and ATP-dependent lysis of macrophages through the formation of membrane pores. P2RX7 is highly expressed in hematopoietic cells and is involved in cell death, host defense against pathogens, and the regulation of inflammatory responses. P2RX7 is also found in the nervous system, microglia, uterine endometrium, and the retina. Mutations in the P2RX7 gene have been associated to major depressive disorder (MDD) and low bone mineral density.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial human P2RX7 recombinant protein (43-334 a.a.) expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2629827 (BioLegend Cat. No. 691002)\u003cbr\u003e\nStructure: 595 amino acids with a predicted molecular weight of 68.3 kD. Multi-pass transmembrane protein.\u003cbr\u003e\nDistribution: Cell membrane and the cytoplasm.\u003cbr\u003e\nFunction: P2RX7 is a ligand-gated cation channel that participates in synaptic transmission and the regulation of immune responses.\u003cbr\u003e\nInteraction: Forms a homotrimer. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230, EMP2, and PTPRB.\u003cbr\u003e\nLigand\/Receptor: ATP.\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience Cell Markers, Signal Transduction\u003cbr\u003e\nAntigen References: 1. Di Virgilio F. 2015. Mol. Cell Oncol. 3:e1010937.2. Sinadinos A, et al. 2015. PLoS Med. 12:e1001888.3. Young CN, et al. 2015. Autophagy 11:113.4. Gavala ML, et al. 2013. J. Leuko. Biol. 94:759.5. Notomi S, et al. 2011. Am. J. Pathol. 179:2798.6. Lucae S, et al. 2006. Hum. Mol. Genet. 15:2438.\u003cbr\u003e\nGene ID: 5027\u003cbr\u003e\nUniProt: View information about P2RX7 on UniProt.org\u003cbr\u003e\nClone: W15180A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Purinergic receptor P2X 7, P2X7, P2Z receptor\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866300534953,"sku":"691002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-691002","provider":"Iright","version":"1.0","type":"link"}