{"product_id":"biolegend-844402","title":"Biolegend, 844402, Purified anti-LRRK2 Antibody (Previously Covance catalog# MMS-5301), 25microl","description":"\u003cp\u003eLeucine-rich repeat kinase 2 (LRRK2), is a member of the leucine-rich repeat kinase family. This protein also functions as a GTPase. Proteins with leucine-rich regions play a role in protein-protein interactions and mediate assembly of the cell's structural framework (cytoskeleton). Mutations in LRRK2 genes have been associated with late-onset Parkinson's disease.\u003cbr\u003e\n25microl\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Antibody is against amino acids 100 - 500 of human LRRK2.\u003cbr\u003e\nFormulation: Phosphate-buffered solution.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 1 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Wang X, et al. 2021. Sci Rep. 11:12900. PubMed\u003cbr\u003e\nRRID: AB_2750047 (BioLegend Cat. No. 844402) AB_2565614 (BioLegend Cat. No. 844401)\u003cbr\u003e\nStructure: This gene is a member of the leucine-rich repeat kinase family and is encoded by the PARK8 gene. The protein is present mainly in the cytoplasm but can be associated with the mitochondrial outer membrane.Expected MW: \u0026gt;200 kD\u003cbr\u003e\nDistribution: Tissue distribution: Lung, Kidney, parathyroid gland, CNS Cellular distribution: cytoplasm, mitochondrion, nucleus, endoplasmic reticulum, lysosome, Golgi apparatus, endosome\u003cbr\u003e\nFunction: LRRK2 interacts with the C-terminal R2 RING finger domain of parkin. LRRK2 positively regulates autophagy through a calcium-dependent activation of the CaMKK\/AMPK signaling pathway. Mutations in this gene have been associated with Parkinson disease.\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neuroinflammation, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Mitochondrial Markers\u003cbr\u003e\nAntigen References: Paisán-Ruíz C, et al. 2004. Neuron. 44(4):595-600. Alegre-Abarrategui J, et al. 2009. Hum. Mol. Genet. 18(21):4022-34. Gómez-Suaga P, et al. 2012. Hum. Mol. Genet. 21(3):511–25. Orenstein SJ, et al. 2013. Nat. Neurosci. 16(4):394–406. Cherra SJ, et al. 2013. Am. J. Pathol. 182(2):474–84.\u003cbr\u003e\nGene ID: 120892\u003cbr\u003e\nUniProt: View information about LRRK2 on UniProt.org\u003cbr\u003e\nClone: 8G10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Leucine-rich repeat serine\/threonine-protein kinase 2, augmented in rheumatoid arthritis 17, AURA17, DARDARIN, PARK8, RIPK7, ROCO2\u003cbr\u003e\nPreviously: Covance Catalog# MMS-5301\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862496333993,"sku":"844402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-844402","provider":"Iright","version":"1.0","type":"link"}