{"product_id":"biolegend-846702","title":"Biolegend, 846702, Purified anti-Caldesmon Antibody, 100μg","description":"\u003cp\u003eCaldesmon is a calmodulin-, actin-, and tropomyosin-binding protein that plays an essential role in smooth muscle and non-muscle contraction. This protein is also involved in cellular mitosis and Schwann cell migration during peripheral nerve regeneration.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Synthetic peptide corresponding to the N-terminus of the human Caldesmon protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested IHC-F, WB - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2629661 (BioLegend Cat. No. 846702)\u003cbr\u003e\nStructure: Caldesmon is a 793 amino acid protein with a molecular mass of 93 kD.\u003cbr\u003e\nDistribution: Tissue distribution: high-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Caldesmon is not expressed in skeletal muscle or heart.. Cellular distribution: cytoskeleton, cytosol, and plasma membrane.\u003cbr\u003e\nFunction: Caldemon mainly regulates actomyosin interactions in smooth muscle and non-muscle cells which affects cell contractions. The protein is also involved in cellular mitosis and in Schwann cell migration during peripheral nerve regeneration.\u003cbr\u003e\nInteraction: Calmodulin, actin, and tropomyosin.\u003cbr\u003e\nBiology Area: Cell Biology, Cell Motility\/Cytoskeleton\/Structure\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: 1. Huber PA. 1997. Int. J. Biochem. Cell Biol. 29(8-9):1047. PubMed 2. Mayanagi T, Sobue K. 2011. Cell. Adh. Migr. 5(2):150. PubMed 3. Wang CL. 2008. Adv. Exp. Med. Biol. 644:250. PubMed 4. Sobue K, Sellers JR. 1991. J. Biol. Chem. 266(19):12115. PubMed\u003cbr\u003e\nGene ID: 800\u003cbr\u003e\nUniProt: View information about Caldesmon on UniProt.org\u003cbr\u003e\nClone: BSB-19\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CDM, CALD1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862917140649,"sku":"846702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-846702","provider":"Iright","version":"1.0","type":"link"}