{"product_id":"biolegend-847501","title":"Biolegend, 847501, Purified anti-β-Amyloid, 1-15 Antibody, 25μg","description":"\u003cp\u003eAlzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor protein (APP) through sequential proteolytic cleavage of APP by β- and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: This antibody was raised against dityrosine cross-linked human Aβ1-40.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested IHC-F, Direct ELISA - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 5.0 µg\/mL is suggested. For immunohistochemistry on frozen tissue sections, a concentration range of 1.0 - 5.0 µg\/mL is suggested. For ELISA applications, a concentration range of 0.01 - 1.0 µg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Frost JL, et al. 2015. Neurobiol Aging. 36(12):3187 (IHC-P) Lardenoije R, et al. 2018. Mol. Cell. Neurosci. 86:1-15. (IHC-P) PubMed\u003cbr\u003e\nRRID: AB_2728567 (BioLegend Cat. No. 847501) AB_2728568 (BioLegend Cat. No. 847502)\u003cbr\u003e\nStructure: Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle. Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.\u003cbr\u003e\nFunction: The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.\u003cbr\u003e\nInteraction: Tau, Prion\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation\u003cbr\u003e\nMolecular Family: APP\/β-Amyloid\u003cbr\u003e\nAntigen References: Puig KL, et al. 2012. Exp Gerontol. 48(7): 608. Selkoe DJ, et al. 2016. EMBO Mol Med. 8(6):595. Walsh DM, et a. 2007. J Neurochem. 101(5):1172.\u003cbr\u003e\nGene ID: 351\u003cbr\u003e\nUniProt: View information about beta-Amyloid on UniProt.org\u003cbr\u003e\nClone: 3A1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: AAA, ABETA, ABPP, AD1, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862384857257,"sku":"847501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-847501","provider":"Iright","version":"1.0","type":"link"}