{"product_id":"biolegend-849803","title":"Biolegend, 849803, HRP anti-Flotillin-1 Antibody, 25μg","description":"\u003cp\u003eThe flotillin family is composed of two highly homologous proteins, flotillin-1 and flotillin-2 that share ~50% amino acid sequence similarity. Flotillins are ubiquitously expressed, membrane-associated proteins, and were shown to be associated with lipid microdomains called membrane rafts. Flotillins are present in various cellular compartments, including the plasma membrane and endosomes, and they have been suggested to function in cellular signaling and membrane trafficking processes, including endocytosis and endosomal trafficking.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Rat, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Human Flotillin-1 recombinant protein corresponding to amino acids 1-270 expressed in E. coli.\u003cbr\u003e\nFormulation: This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone specifically recognizes Flotillin-1 but not Flotillin-2, verified using WB.\u003cbr\u003e\nRRID: AB_2728577 (BioLegend Cat. No. 849803)\u003cbr\u003e\nStructure: Flotillin-1 is a 427 amino acid protein with a molecular mass of 47 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Flotillin-1 is ubiquitously expressed. Cellular distribution: Flotillin-1 is mainly expressed in the cytosol and endosomes.\u003cbr\u003e\nFunction: Flotillins are thought to interact with the cytoskeleton and function in a number of cellular processes such as endocytosis.\u003cbr\u003e\nInteraction: Flotillin-1 interacts with cbl-associated protein\/ponsin (CAP).\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance\u003cbr\u003e\nAntigen References: 1. Otto G et al., 2011. Journal of Cell Science. 124: 3933.\u003cbr\u003e\nGene ID: 10211\u003cbr\u003e\nUniProt: View information about Flotillin-1 on UniProt.org\u003cbr\u003e\nClone: W16108A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Flotillin 1, Flot-1, Integral Membrane Component of Caveolae\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866304073897,"sku":"849803","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-849803","provider":"Iright","version":"1.0","type":"link"}