{"product_id":"biolegend-851501","title":"Biolegend, 851501, Purified anti-DJ-1 (PARK7) Antibody, 25μg","description":"\u003cp\u003eDJ-1 (PARK7) belongs to the peptidase C56 family of proteins and is expressed in almost all human cells and tissues. DJ-1 is a multi-functional protein associated with mitochondrial function, mitophagy, and male fertility. It acts as an oxidative stress sensor, redox-sensitive chaperone and protease. Therefore, the protein has an important role in cell protection against oxidative stress and cell death. DJ-1 is also associated with prostate cancer, and specific mutations of the protein are linked to autosomal recessive, early onset Parkinson’s disease.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human DJ-1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedDirect ELISA, IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For Direct ELISA, a concentration range of 0.002 - 1.0 µg\/mL is recommended. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2721732 (BioLegend Cat. No. 851501) AB_2721733 (BioLegend Cat. No. 851502)\u003cbr\u003e\nStructure: Human DJ-1 is a 189 amino acid protein with an apparent molecular weight of 20 kD. The protein consists of 7 β-strands and 7 α-helices, and exits as a dimer.\u003cbr\u003e\nDistribution: Tissue distribution: Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in brain and placenta. Cellular distribution: Mitochondria, nucleus, cytosol, plasma membrane, and extracellular.\u003cbr\u003e\nFunction: DJ-1 functions as an oxidative stress sensor and redox-sensitive chaperone.\u003cbr\u003e\nInteraction: PINK1, Parkin, EFCAB6\/DJBP, OTUD7B, BBS1, HIPK1, CLCF1 and MTERF.\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance\u003cbr\u003e\nMolecular Family: Mitochondrial Markers\u003cbr\u003e\nAntigen References: 1. Saito Y. 2014. J. Clin. Biochem. Nutr. 54(3):138-44. PubMed 2. Ariga H, et al. 2013. Oxid. Med. Cell Longev. 2013:683920. PubMed 3. Bonifati V, et al. 2003. Science (5604): 256–9. PubMed\u003cbr\u003e\nGene ID: 11315\u003cbr\u003e\nUniProt: View information about DJ-1 on UniProt.org\u003cbr\u003e\nClone: A16125E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Protein DJ-1, oncogene, DJ1, PARK7, Parkinson disease protein 7, Parkinsonism-Associated Deglycase, HEL-S-67p, epididymis secretory sperm binding protein Li 67p, GATD2, Protein Deglycase DJ-1\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864401825961,"sku":"851501","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-851501","provider":"Iright","version":"1.0","type":"link"}