{"product_id":"biolegend-853706","title":"Biolegend, 853706, Biotin anti-Synapsin I\/II\/III Antibody, 100μg","description":"\u003cp\u003eSynapsins are a family of proteins involved in neurotransmitter release at the chemical synapses. Synapsins anchor synaptic vesicles to the cytoskeletal structures at the presynaptic terminal. Upon receiving an action potential, phosphorylation of synapsins, possibly by PKA, leads to the release of synaptic vesicles from cytoskeletal structures. This allows membrane docking and fusion of synaptic vesicles with the presynaptic membrane and neurotransmitter release.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant protein corresponding to amino acids 362-450 of human Synapsin I\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.001 - 0.01 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.5 - 5.0 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Yasom S, et al. 2022. FASEB Bioadv. 4:408. PubMed\u003cbr\u003e\nRRID: AB_2801203 (BioLegend Cat. No. 853705) AB_2801204 (BioLegend Cat. No. 853706)\u003cbr\u003e\nStructure: Synapsin I is a 704 amino acid protein with an apparent molecular mass of ~74 kD. Synapsin II is a 582 amino acid protein with an apparent molecular mass of ~63 kD. Synapsin III is a 580 amino acid protein with an apparent molecular mass of ~63 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Mainly in the central nervous system. Also expressed in testis. Cellular distribution: Cytosol, nucleus, and plasma membrane.\u003cbr\u003e\nFunction: Synapsins are involved in the regulation of synaptic vesicle fusion and neurotransmitter release at the presynaptic terminals.\u003cbr\u003e\nInteraction: CAPON (Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein), PKA\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology\u003cbr\u003e\nMolecular Family: Presynaptic proteins, Synaptic Vesicle Trafficking\/Endocytosis\u003cbr\u003e\nAntigen References: Greengard P, et al. 1993. Science. 259(5096):780 Milovanovic D, et al. 2017. Neuron. 93(5):995 Evergren E, et al. 2007. J. Neurosci. Res. 85(12):2648\u003cbr\u003e\nGene ID: 685368548224\u003cbr\u003e\nUniProt: View information about Synapsin I\/II\/III on UniProt.org\u003cbr\u003e\nClone: A17080A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: SYN, Synapsin, Synapsin I, Synapsin II, Synapsin III\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866047238313,"sku":"853706","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-853706","provider":"Iright","version":"1.0","type":"link"}