{"product_id":"biolegend-859801","title":"Biolegend, 859801, Purified anti-LDHB Antibody, 25μg","description":"\u003cp\u003eLactate Dehydrogenase B (LDHB) is one of the subunits of the lactate dehydrogenase enzyme that catalyzes the synthesis of (S)-Lactate from pyruvate.  LDHB was shown to be a downstream mediator of the mTOR signaling pathway that plays a critical role in hyperactive mTOR-mediated tumorigenesis, indicating it as potential therapeutic target for cancer and other diseases caused by aberrant mTOR signaling.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Lactate Dehydrogenase B (LDHB) expressed in E.coli\u003cbr\u003e\nFormulation: 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application. For formalin-fixed paraffin-embedded immunohistochemical staining, a concentration range of 1 - 5 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2810734 (BioLegend Cat. No. 859801)\u003cbr\u003e\nStructure: LDHB is a 334 amino acid protein with an apparent molecular mass of ~37 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Cytosol\u003cbr\u003e\nFunction: LDHB is part of the lactate synthesis pathway that synthesizes S-Lactate from pyruvate\u003cbr\u003e\nInteraction: Forms Homotetramers\u003cbr\u003e\nCell Type: Mature Neurons\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cancer Biomarkers\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: Swiderek K and Paneth P. 2011. Arch. Biochem Biophys. 505(1):33 Zha X, et al. 2011. Cancer Res. 71(1):13\u003cbr\u003e\nGene ID: 39451683224534\u003cbr\u003e\nUniProt: View information about LDHB on UniProt.org\u003cbr\u003e\nClone: BL28598\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: LDHB\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866452021417,"sku":"859801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-859801","provider":"Iright","version":"1.0","type":"link"}