{"product_id":"biolegend-862202","title":"Biolegend, 862202, Purified anti-Myelin Protein Zero Antibody, 100μg","description":"\u003cp\u003eMyelin protein zero (MPZ), is a membrane glycoprotein mainly expressed in the peripheral nervous system (PNS). It is the major structural component of the myelin sheath, and accounts for at least 50% of all proteins in the PNS. MPZ is expressed by Schewann cells. Mutations in MPZ have been associated with myelin deficiency, which may lead to neuropathies including charcot-Marie-Tooth and Dejerine-Sottas diseases.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested WB - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg\/mL is suggested. For western blotting, the suggested use of this reagent is 1 - 5 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Yoshimura K, et al. 1996. Neurosci Res. 25(1):41 (WB, IHC, ELISA)\u003cbr\u003e\nRRID: AB_2801241 (BioLegend Cat. No. 862201) AB_2801242 (BioLegend Cat. No. 862202)\u003cbr\u003e\nStructure: MPZ is a 248 amino acid protein with an apparent molecular mass of ~ 28 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Peripheral nervous system Cellular Distribution: Plasma membrane, extracellular, endoplasmic reticulum, and lysosome\u003cbr\u003e\nFunction: MPZ is an adhesion molecule involved in the formation of myelin sheath in the peripheral nervous system.\u003cbr\u003e\nInteraction: Forms homodimer and homotetramer\u003cbr\u003e\nBiology Area: Neurodegeneration, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Chiò A and Lauria G. 2016. Lancet Neurol. 15(1):12 Brennan KM, et al. 2015. Neurosci Lett. 596:14 Tazir M, et al. 2014. J Neurol Sci. 347(1-2):14\u003cbr\u003e\nGene ID: 43591752824564\u003cbr\u003e\nUniProt: View information about Myelin Protein Zero on UniProt.org\u003cbr\u003e\nClone: 58A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MPZ, Myelin Protein Zero\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864149184681,"sku":"862202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-862202","provider":"Iright","version":"1.0","type":"link"}