{"product_id":"biolegend-869401","title":"Biolegend, 869401, Purified anti-Desmoglein 2 Antibody, 25μg","description":"\u003cp\u003eDesmoglein 2 (DSG2) is a calcium-binding adhesion molecule that is highly expressed in epithelial cells and cardiomyocytes in vertebrates. DSG2 mainly locates to the intracellular adhesive junction called desmosome, which is a structure that functions in cell-to-cell adhesion. Clinically, mutations in DSG2 are mostly linked to cardiomyopathy. A recent GWAS study has shown that DSG2 is 1 of the 20 genetic risk factors that are associated with Alzheimer's disease.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg\/ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2814633 (BioLegend Cat. No. 869401) AB_2814634 (BioLegend Cat. No. 869402)\u003cbr\u003e\nStructure: DSG2 is a 1118 amino acid protein with predicted molecular mass of ~122 kD and observed molecular mass of ~150 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Ubiquitously expressed Cellular Distribution: Plasma membrane\u003cbr\u003e\nFunction: DSG2 is localized to desmosomes and functions in cell-to-cell adhesion.\u003cbr\u003e\nInteraction: DSG2 is an integral component of desmosomes.\u003cbr\u003e\nCell Type: Epithelial cells\u003cbr\u003e\nBiology Area: Cell Adhesion, Neurodegeneration, Neuroinflammation, Synaptic Biology\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Kim JH. 2018. Dement Neurocogn Disord. 10.12779\/dnd.2018.17.4.131. Harrison OJ, et al. 2016. Proc. Natl. Acad. Sci U S A. 113:7160-5.\u003cbr\u003e\nGene ID: 1829\u003cbr\u003e\nUniProt: View information about Desmoglein 2 on UniProt.org\u003cbr\u003e\nClone: 8E5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: DSG2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862494171305,"sku":"869401","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-869401","provider":"Iright","version":"1.0","type":"link"}