{"product_id":"biolegend-869702","title":"Biolegend, 869702, Purified anti-TBL1 Antibody, 100μg","description":"\u003cp\u003eTBL1 is a protein that has sequence similarity with WD40 repeat-containing protein family. TBL1 plays an essential role in signal transduction, gene regulation, vesicle trafficking, and cytoskeletal arrangement through protein-protein interactions. TBL1 is also found as a component of nuclear receptor corepressor complexes through interaction with histone deacetylase 3, and is involved in Notch signaling. It is associated with diseases including ocular albinism and atrial septal defect 4.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Purified recombinant human TBL1 protein fragments expressed in E.coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2820178 (BioLegend Cat. No. 869701) AB_2820179 (BioLegend Cat. No. 869702)\u003cbr\u003e\nStructure: TBL1 is a 577 amino acid protein with a predicted and observed molecular mass of ~62 kD.\u003cbr\u003e\nDistribution: Tissue Distribution: Brain, kidney, liver, heart, and lung Cellular Distribution: Nucleus\u003cbr\u003e\nFunction: TBL1 is involved in the regulation of gene expression, RNA processing, vesicle trafficking, and cytoskeleton assembly.\u003cbr\u003e\nInteraction: HDAC3, Notch1\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytoskeletal Proteins, Nuclear Markers\u003cbr\u003e\nAntigen References: Perissi V, et al. 2004. Cell. 116(4):511-26. Li J, et al. 2008. Nat Cell Biol. 10(2):160-9.\u003cbr\u003e\nGene ID: 690721372302711\u003cbr\u003e\nUniProt: View information about TBL1 on UniProt.org\u003cbr\u003e\nClone: 4H2-D5-E9\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Transducin Beta Like 1 X-Linked, F-Box-Like\/WD Repeat-Containing Protein TBL1X, SMAP55, EBI\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862418411689,"sku":"869702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-869702","provider":"Iright","version":"1.0","type":"link"}