{"product_id":"biolegend-870402","title":"Biolegend, 870402, Purified anti-Parkin Antibody, 100μg","description":"\u003cp\u003eParkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile parkinsonism (AR-JP).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant full-length human Parkin protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Tokarew, J., et al. 2021. Acta Neuropathologica 2021. 141(5): 725-754. PubMed\u003cbr\u003e\nRRID: AB_2820192 (BioLegend Cat. No. 870401) AB_2820193 (BioLegend Cat. No. 870402)\u003cbr\u003e\nStructure: Human Parkin is a 465 amino acid protein with a predicted molecular mass of ~52 kD.\u003cbr\u003e\nDistribution: Tissue distribution: Brain, heart, testis, and skeletal muscle Cellular distribution: Cytosol, mitochondria, nucleus, and endoplasmic reticulum\u003cbr\u003e\nFunction: Parkin is involved in protein ubiquitination, protein degradation, mitochondria function, and neurodegeneration.\u003cbr\u003e\nInteraction: Ubiquitin, PINK1\u003cbr\u003e\nLigand\/Receptor: BCL2, SYT11, CCNE1, GPR37, RHOT1\/MIRO1, MFN1\u003cbr\u003e\nCell Type: Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Ubiquitin\/Protein Degradation\u003cbr\u003e\nMolecular Family: Ligases\u003cbr\u003e\nAntigen References: Tay SP, et al. 2010. J Biol Chem. 285: 29231-8. Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8.\u003cbr\u003e\nGene ID: 5071\u003cbr\u003e\nUniProt: View information about Parkin on UniProt.org\u003cbr\u003e\nClone: A15165E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862518845609,"sku":"870402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-870402","provider":"Iright","version":"1.0","type":"link"}