{"product_id":"biolegend-935302","title":"Biolegend, 935302, Purified anti-c-Myb Antibody, 100μg","description":"\u003cp\u003ec-Myb is a proto-oncogene protein that functions as a transcription factor and a key regulator of cell proliferation and differentiation. As a DNA binding protein, it plays a role in regulating cell cycle and gene expression. c-Myb expression is elevated in hematopoietic progenitor cells and decreases following cell differentiation. Increased or aberrant expression of c-Myb as well as duplication and c-terminal deletion have been reported in various malignancies suggesting it plays a critical role in tumorigenesis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant protein of human MYB corresponding to amino acid residues 391-640\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg\/mL. For immunoprecipitation, the suggested use of this reagent is 2.5 µg\/test. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone is predicted to recognize isoforms 1, 2, 4, 7, and 8 based off complete sequence homology of the immunizing peptide and the corresponding region in each isoform.ICC test failed. The clone incorrectly stains the negative control in the cytosol.\u003cbr\u003e\nRRID: AB_2832892 (BioLegend Cat. No. 935301) AB_2832893 (BioLegend Cat. No. 935302)\u003cbr\u003e\nStructure: Myb is a 640 amino acid protein with a predicted molecular weight of 72 kD.\u003cbr\u003e\nDistribution: Nucleus\/differential expression\u003cbr\u003e\nFunction: Gene transcription, cell proliferation and differentiation\u003cbr\u003e\nCell Type: Epithelial cells, Leukemia\u003cbr\u003e\nBiology Area: Cell Biology, Stem Cells, Transcription Factors\u003cbr\u003e\nAntigen References: Schulz C, et al. 2012. Science. 336(6077):86-90. Martin C, et al. 1997. Trends Genet. 13(2):67-73. Mucenski M, et al. 1991. Cell. 65(4):677-89.\u003cbr\u003e\nGene ID: 4602\u003cbr\u003e\nUniProt: View information about c-Myb on UniProt.org\u003cbr\u003e\nClone: W16209A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Myb, c-Myb, Transcriptional activator Myb, Proto-oncogene c-Myb, MYB Proto-Oncogene, Transcription Factor\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866309021865,"sku":"935302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-935302","provider":"Iright","version":"1.0","type":"link"}