{"product_id":"biolegend-940901","title":"Biolegend, 940901, Purified anti-SARS-CoV-2 Nucleocapsid Antibody, 25μg","description":"\u003cp\u003eSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a single stranded RNA virus that belongs in a family of viruses known as coronaviruses. SARS-CoV-2 infection, known as COVID-19, was declared a pandemic in 2020 and among other symptoms leads to respiratory infection, pulmonary failure which can be fatal. SARS-CoV-2 is structurally composed of 4 main proteins (e.g. spike glycoprotein, envelope glycoprotein, membrane glycoprotein and nucleocapsid protein) and several accessory proteins.  The SARS-CoV-2 Nucleocapsid (N) is an abundant protein, that binds to the viral RNA and helps stabilize it. It has been proposed that N protein forms bimolecular condensates that both regulate viral replication and modulate the host response to the virus following infection. N protein is a major antigen that the host immune response is directed to following SARS CoV-2 infection making it a promising candidate for vaccine development and drug therapy.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: SARS-CoV-2\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: SARS-CoV-2 nucleocapsid recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested Direct ELISA - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.125 - 1.0 µg\/mL. For the Direct ELISA application, a concentration of 2.5 ng\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: SARS-CoV-2 is 90% homologous to SARS-CoV. Cross reactivity of anti-SARS-CoV-2 nucleocapsid antibody (clone A20087F) with SARS-CoV has not been tested.\u003cbr\u003e\nRRID: AB_2888743 (BioLegend Cat. No. 940901) AB_2888743 (BioLegend Cat. No. 940902)\u003cbr\u003e\nStructure: SARS-CoV-2 is a 419 amino acid protein with an expected molecular weight of 46 kD.\u003cbr\u003e\nDistribution: Viral nucleoprotein, host cell Golgi apparatus\u003cbr\u003e\nFunction: RNA binding, transcription regulation\u003cbr\u003e\nBiology Area: COVID-19\u003cbr\u003e\nAntigen References: Zeng W, et al. 2020. Biochem Biophys Res Commun. 527:618-623. Yoshimoto FK. 2020. Protein J. 39:198-216. Cascarina SM \u0026amp; Ross ED. 2020. FASEB J. fj.202001351.\u003cbr\u003e\nGene ID: 43740575\u003cbr\u003e\nUniProt: View information about Viral Protein on UniProt.org\u003cbr\u003e\nClone: A20087F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Nucleocapsid phosphoprotein, N, Nucleoprotein\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866070339753,"sku":"940901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-940901","provider":"Iright","version":"1.0","type":"link"}