{"product_id":"cobetter-h-mb050t25-lp","title":"Cobetter, H-MB050T25-LP, Consieve Ultrafiltration Cassettes Holder 0.5m², with 3 Valves and 2 Gauges","description":"\u003cp\u003eCheck this product with a package size of 0.5m² on Iright. Due to the forces required to drive a tangential flow filtration process, a robust holder is needed to provide support against internal pressures. Further, the holder and gaskets can provide the liquid distribution of the feed, retentate, and permeate lines.\u003cbr\u003e\nCobetter TFF Cassette Holder (0.5m²) is available for use with 0.5m² or 2.5m² cassettes, with a maximum cassette capacity of 5m². Suitable for applications with throughput volumes more than 50 L.\u003cbr\u003e\nSpecifications\u003c\/p\u003e\n\n\u003cp\u003eConnections\u003cbr\u003e\nConnectors\u003cbr\u003e\nT20\u003cbr\u003e\nMaterials\u003cbr\u003e\nFilter Plate Material\u003cbr\u003e\n316L stainless steel\u003cbr\u003e\nO-rings\u003cbr\u003e\nSilicone\u003cbr\u003e\nPhysical Properties\u003cbr\u003e\nApplications\u003cbr\u003e\nPilot Production, Large Scale Production\u003cbr\u003e\nSurface Treatment\u003cbr\u003e\nPolishing\u003cbr\u003e\nPressure Withstand\u003cbr\u003e\n0.6 MPa\u003cbr\u003e\nCassette Capacity\u003cbr\u003e\n0.46m² or 2.33m² cassettes\u003cbr\u003e\nThroughput\u003cbr\u003e\n\u0026gt;50 L\u003cbr\u003e\nDimensions\u003cbr\u003e\n28 x 9 x 25 cm\u003cbr\u003e\nWeight\u003cbr\u003e\n24 kg\u003cbr\u003e\nAccessories\u003cbr\u003e\n3 PP Manual Extrusion Valves\u003cbr\u003e\nBrand: Fujikin\u003cbr\u003e\nConnector: TC25\u003cbr\u003e\nPipe Diameter: 3\/4 inch\u003cbr\u003e\nPTFE+EPDM diaphragm\u003cbr\u003e\n2 Pressure Gauges\u003cbr\u003e\nTC Connection\u003cbr\u003e\nMonitoring Range: 0-6 bar\u003cbr\u003e\nPackage\u003cbr\u003e\nPack Size\u003cbr\u003e\n1 pcs\u003cbr\u003e\nPackaging\u003cbr\u003e\nIndividually packed\u003cbr\u003e\nApplications\u003cbr\u003e\nProcess development and pilot-scale or large-scale production in biopharmaceutical and pharmaceutical ultrafiltration. Q: What is tangential flow filtration (TFF)?\u003cbr\u003e\nTangential flow filtration (TFF) is a method in which the feed flows along the membrane surface, generating tangential shear to reduce membrane fouling and clogging. TFF is commonly applied as ultrafiltration (1–1000 kDa) or microfiltration (0.1–0.65 µm).\u003cbr\u003e\nQ: How to choose the appropriate ultrafiltration membranes?\u003cbr\u003e\nFor most ultrafiltration and dialysis applications, both PES and RC membranes are suitable choices.\u003cbr\u003e\nPES membranes can meet a wide range of application needs for most protein and small-molecule products, such as antibodies, APIs, and vaccines.\u003cbr\u003e\nRC membranes should be considered when preparing high-concentration formulations, applications containing organic solvents (e.g., ADC products), or concentration\/exchange of linear molecules including oligonucleotides and peptides.\u003cbr\u003e\nFor new target molecules, it is recommended to test both membrane types during standard sample handling and process optimization.\u003cbr\u003e\nQ: How to select the appropriate cut-off for ultrafiltration cassettes?\u003cbr\u003e\nChoose the membrane cut-off based on the size or molecular weight of the substance to be separated or retained:\u003cbr\u003e\nAntibody proteins: 30 kDa or 50 kDa\u003cbr\u003e\nViral or vaccine products: 100–1000 kDa\u003cbr\u003e\nFor API products, an appropriate molecular weight cut-off (MWCO) can be selected from the range of 1 kDa, 2 kDa, 3 kDa, 5 kDa, 8 kDa, and 10 kDa according to the process objectives.\u003cbr\u003e\nIf the molecular weight of the target substance is unknown, preliminary testing can be performed using ultrafiltration centrifugal devices with different cut-offs to identify the most suitable molecular weight retention.\u003cbr\u003e\nQ: What materials and cut-offs are available for Cobetter cassettes?\u003cbr\u003e\nUltrafiltration cassettes are available in PES and RC membranes, with cut-offs ranging from 1–1000 kDa.\u003cbr\u003e\nMicrofiltration cassettes are available in PES and PVDF membranes, with pore sizes ranging from 0.1–0.65 µm.\u003cbr\u003e\nQ: Can ultrafiltration cassettes be reused?\u003cbr\u003e\nYes. Ultrafiltration cassettes can be reused by selecting appropriate cleaning methods. However, due to changes such as declining membrane flux and increased permeation, the cassettes should be replaced periodically as needed.\u003cbr\u003e\nQ: How should ultrafiltration cassettes be cleaned?\u003cbr\u003e\nThey can be cleaned by circulating 0.1-0.5 M sodium hydroxide (NaOH) solution. If cleaning effectiveness is insufficient, adjustments can be made by either of the following methods:\u003cbr\u003e\nIncreasing the cleaning solution temperature (\u0026lt;45 °C)\u003cbr\u003e\nAdding sodium hypochlorite (NaClO, 500 ppm)\u003cbr\u003e\nExtending the cleaning time\u003cbr\u003e\nFor difficult-to-clean feed components, alternative cleaning solutions such as acidic solutions, alcohols, or surfactants may also be used.\u003cbr\u003e\nQ: Are Cobetter ultrafiltration membrane cassettes compatible with hardware from other companies?\u003cbr\u003e\nYes. They can be installed in holders from Merck, Pall, and similar manufacturers. But it is necessary to ensure proper torque and perform integrity testing.\u003cbr\u003e\nFor Sartorius holders, a specific adapter plate is required for proper installation.\u003c\/p\u003e","brand":"Cobetter","offers":[{"title":"Default Title","offer_id":46778415382697,"sku":"H-MB050T25-LP","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cobetter-h-mb050t25-lp","provider":"Iright","version":"1.0","type":"link"}