{"product_id":"cobetter-sah06001-6m20r1060g","title":"Cobetter, SAH06001-6M20R1060G, ATF Hollow Fiber Filter for Perfusion Cell Culture Process, 1\/pk","description":"Check this product with a package size of ATF6 (50-200L) \/ Single-use Assembly (Gamma Irradiated) \/ 0.2 μm-R on Iright. Cobetter ATF hollow fiber product is specially developed for perfusion cell culture process. The main body of the series is made of Cobetter's self-produced polyethersulfone (PES) hollow fiber membrane filament. The raw material has been tested and validated to have the features of low E\u0026amp;L profile and good biocompatibility. Cobetter ATF hollow fiber product is suitable for cell culture processes such as medium exchanging, continuous cell clarifying and harvesting from 1L to 2000L culture scale, which meets the requirements from R\u0026amp;D to commercialization. \nCobetter ATF hollow fiber product is manufactured following strict quality control standards. The production process is carried out in accordance with the ISO9001-2015 quality management system, and is all done under ISO Class 7. Each hollow fiber products will passed the integrity test and water flux test before release. Quality documentation can be provided to help bio-pharmaceutical customers' safety production and audit requirements.\nSpecifications\n\nATF2\nATF6\nATF10\nCulture Volume\n1-10L\n50-200L\n200-1000L\nFormat\nStainless-steel, Single-use\nMembrane\nPolyethersulfone (PES)\nPore Size\n50kd, 0.2μm\nNo. of Fibers\n75\n1440\n6720\nEffective Filtration Area\n0.13 m²\n2.5 m²\n11 m²\nLength\n60 cm\nVolume Exchange\n0.1 L\n1.3 L\n6 L\nFlow Range\n0.3-1.5 LPM\n5-20 LPM\n20-90 LPM\nRecommended Flow Rate\n5-15 mL\/min\/fiber3-8 L\/min\/m²\n\nFeatures\n100% product integrity test;\nLow bioburden, no cytotoxicity;\nADCF, good biocompatibility;\nPortable, flexible connection to 1L-2000L single-use bioreactors\nSingle-use format available. Gamma irradiated and ready to use. Eliminating the need for complex on-site assembly and sterilization operations, improving manufacturing efficiency;\nAll series of hollow fiber membrane columns can withstand regular autoclaving sterilization procedures, reducing the investment of high-cost sterilization equipment;\nBreakthrough the limitation of cell density in batch\/ fedBatch process while maintaining high cell viability.\nApplications\nPefusion cell culture process, including:\nN-1 high cell density seed culturing\nMedium exchanging and target product harvesting in dynamic\/continuous perfusion cell culturing\nMedium exchanging in concentrated fed-batch cell culturing\nCell lysis clarification and concentration\nMultiple fields of cell\/microbial culture including:\nBio-pharmaceuticals such as antibody, vaccine and CGT\nFood industries such as culture meat and wine-making\nQuality Assurance\nISO 9001:2015 quality management system\nISO class 7 manufacturing site\n100% product integrity test\nADCF raw material，meets the requirement of FDA 21CFR177-182 indirect food additives\nMeets the requirement of ISO 11137 sterilization validation\nMeets the requirement of USP \u0026lt;87\u0026gt; in Vitro Biological Reactivity TestMeets the requirement of USP \u0026lt;88\u0026gt; Biological Reactivity Test, in Vivo for Class VI plastics\nAqueous extraction contains \u0026lt; 0.25 EU\/mL as determined by Limulus Amebocyte Lysate (LAL), USP \u0026lt;85\u0026gt;\nParticulate matter in the product eluent meets the requirement in USP \u0026lt;788\u0026gt; for large volume parenterals\nProduct validation guide and COA available\nSingle-Use ATF 2 Schematic Diagram\n \nSingle-Use ATF 6 Schematic Diagram\n \nSingle-Use ATF 6 Tubing Assembly Schematic Diagram\n \nSingle-Use ATF 10 Schematic Diagram\n \nSingle-Use ATF 10 Tubing Assembly Schematic Diagram Q: What are the advantages of hollow fiber compared to cassette (flat-sheet) modules?\n1. More open flow channels and relatively lower shear.\n2. High packing density and large surface area per module enable a compact system footprint with minimal hold-up volume.\n3. Robust handling of challenging feed streams, including high solids content or viscosity.\n4. Suited for large-volume, high-flow continuous processing in drug manufacturing, such as for insulin and animal vaccines.\nQ: What are the applications of hollow fiber technology?\nConcentration and buffer exchange of viral vaccines.\nConcentration and diafiltration of Cell and Gene Therapy (CGT) products.\nPurification, concentration, and buffer exchange of mRNA products.\nBiomass harvesting from bacterial fermentation, and clarification\/removal of cell debris from cell culture lysates.\nCell retention in perfusion culture (ATF system).","brand":"Cobetter","offers":[{"title":"Default Title","offer_id":46778521288873,"sku":"SAH06001-6M20R1060G","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cobetter-sah06001-6m20r1060g","provider":"Iright","version":"1.0","type":"link"}