{"product_id":"cst-10727s","title":"CST,  10727S, MDL-28170 (Calpain Inhibitor III)","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nMDL-28170 (Calpain Inhibitor III) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.30 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nMDL-28170 (Calpain Inhibitor III) is a potent and selective inhibitor of Calpain-1 (mu-type) and Calpain-2 (M-type) (1). This cell-permeable small molecule has been shown to cross the blood-brain barrier and has demonstrated neuroprotective effects in several rodent models making it a useful tool for studying neurodegenerative disease and neurotrauma as well as ischemic reperfusion (2,3). MDL-28170 (Calpain Inhibitor III) has an EC value of 14 μM when tested in a cell-based assay and has shown to be an effective antiviral agent, inhibiting SARS-CoV replication in Vero 76 cells with an IC value of 10 μM (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCalpain; Calpain Inhibitor III; MDL-28170; MDL28170; N-Benzyloxycarbonylvalylphenylalaninal; Z-Val-Phe-CHO","brand":"CST","offers":[{"title":"Default Title","offer_id":46800691593385,"sku":"10727S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-10727s","provider":"Iright","version":"1.0","type":"link"}