CST, 11990S, Tensin 2 Antibody

Polyclonal Antibody for studying tensin 2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Tensin 2 Antibody (CST #11990) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Tensin 2 Antibody recognizes endogenous levels of total Tensin 2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg155 of human Tensin 2 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Tensin 2 belongs to the Tensin family of cytoskeletal proteins that includes Tensin 1-3 and Cten, which couple integrins to the actin cytoskeleton (1). Tensin proteins contain SH2 and phosphotyrosine binding (PTB) domains, which enable interaction with diverse signaling molecules and proteins. Tensin family proteins play important roles in signal transduction, cell proliferation, and motility (2-5). Tensin 2 is localized to focal adhesions of various tissues with highest expression in the heart, kidney, and liver (6,7). Tensin 2 inhibits Akt/PKB signaling via a phosphatase tensin-type domain (8). However, Tensin 2 also mediates thrombopoietin/c-Mpl signaling, which promotes Akt signaling (9). Interaction with Tensin 2 is essential for the tumor suppressor function of Deleted in Cancer 1 (DLC1) (6,10,11). Alternate Names C1 domain-containing phosphatase and tensin homolog; C1-TEN; C1TEN; DKFZp686D13244; FLJ16320; KIAA1075; TENC1; tensin 2; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain-containing phosphatase; Tensin-2; Tensin-like C1 domain-containing phosphatase; TNS2 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 145-155 SOURCE: Rabbit