{"product_id":"cst-12001d","title":"CST,  12001D, PathScan® Phospho-SMAD2 (Ser465\/467)\/SMAD3 (Ser423\/425) Sandwich ELISA Kit","description":"ELISA Kit for studying Smad3 (Ser423\/Ser425) phosphate\/Smad2 (Ser465\/Ser467) phosphate in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPathScan\nSpecies Reactivity: Human, Mouse, Mink\n\u003cb\u003eBackground\u003c\/b\u003e\nMembers of the SMAD family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of SMADs have been defined: the receptor-regulated SMADs (R-SMADs), which include SMAD1, 2, 3, 5, and 9; the common-mediator SMAD (co-SMAD), SMAD4; and the antagonistic or inhibitory SMADs (I-SMADs), SMAD6 and 7 (1-5). Activated type I receptors associate with specific R-SMADs and phosphorylate them on a conserved carboxy-terminal SSXS motif. The phosphorylated R-SMADs dissociate from the receptor and form a heteromeric complex with SMAD4, initiating translocation of the heteromeric SMAD complex to the nucleus. Once in the nucleus, SMADs recruit a variety of DNA binding proteins that function to regulate transcriptional activity (6-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp586N0721; DKFZp686J10186; hMAD-2; hMAD-3; hSMAD2; hSMAD3; HSPC193; HsT17436; JV15-2; JV18; JV18-1; LDS1C; LDS3; MAD homolog 2; MAD homolog 3; mad homolog JV15-2; mad protein homolog; Mad protein homolog; Mad-related protein 2; MAD, mothers against decapentaplegic homolog 2; MAD, mothers against decapentaplegic homolog 3; Mad3; MADH2; MADH3; MADR2; MGC22139; MGC34440; MGC60396; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 2; Mothers against DPP homolog 3; Sma- and Mad-related protein 2; SMA- and MAD-related protein 3; SMAD 2; SMAD 3; SMAD family member 2; SMAD family member 3; SMAD, mothers against DPP homolog 2; SMAD, mothers against DPP homolog 3; SMAD2; SMAD3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M Mi","brand":"CST","offers":[{"title":"Default Title","offer_id":46800572678313,"sku":"12001D","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12001d","provider":"Iright","version":"1.0","type":"link"}