{"product_id":"cst-12019s","title":"CST,  12019S, ADRM1 (D9Z1U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ADRM1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ADRM1 (D9Z1U) Rabbit Monoclonal Antibody (CST #12019) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nADRM1 (D9Z1U) Rabbit Monoclonal Antibody recognizes endogenous levels of total ADRM1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human ADRM1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCurrently, there are five ubiquitin receptors associated with the proteasome: two proteasome subunits, Rpn10\/S5a\/PSMD4 and Rpn13\/ADRM1 (Adhesion-regulating molecule 1), and three families of shuttling factors, Rad23, Dsk2, and Ddi1. ADRM1 is a ubiquitin receptor of the proteasome (1,2) that binds ubiquitin via a pleckstrin homology domain known as the pleckstrin-like receptor for ubiquitin (Pru) domain. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5\/UCH37 (3-5), perhaps serving as a mechanism to accelerate ubiquitin chain disassembly. A murine knockout results in defective gametogenesis, thus highlighting a physiologic role for endogenous ADRM1 in mammalian development (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n110 kDa cell membrane glycoprotein; adhesion regulating molecule 1; Adhesion-regulating molecule 1; ADRM1; ARM-1; ARM1; GP110; hRpn13; M(r) 110,000 surface antigen; MGC29536; Proteasomal ubiquitin receptor ADRM1; Proteasome regulatory particle non-ATPase 13; proteasome ubiquitin receptor; regulatory particle non-ATPase 13; Rpn13; Rpn13 homolog\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 45\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797564281001,"sku":"12019S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12019s","provider":"Iright","version":"1.0","type":"link"}