{"product_id":"cst-12029s","title":"CST,  12029S, TRXR2\/TXNRD2 (3F2-E12-F10) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying TXNRD2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TRXR2\/TXNRD2 (3F2-E12-F10) Mouse Monoclonal Antibody (CST #12029) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTRXR2\/TXNRD2 (3F2-E12-F10) Mouse Monoclonal Antibody recognizes endogenous levels of total TRXR2\/TXNRD2 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human TRXR2\/TXNRD2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS) (1-4). There are three known mammalian thioredoxin reductases: TRXR1\/TXNRD1 (cytosolic), TRXR2\/TXNRD2 (mitochondrial), and TRXR3\/TXNRD3 (testis-specific) (1). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation (5). TRXR2 is critical for normal heart development and function (1,4). TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure (4). In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy (1). A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGCCD5; KIAA1652; Selenoprotein Z; SelZ; thioredoxin reductase 2; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR-beta; TR3; TRXR2; TXNRD2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 56\nSource\/Isotype: Mouse IgG3","brand":"CST","offers":[{"title":"Default Title","offer_id":46797564444841,"sku":"12029S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12029s","provider":"Iright","version":"1.0","type":"link"}