{"product_id":"cst-12098s","title":"CST,  12098S, PGAM1 (D3J9T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PGAM1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PGAM1 (D3J9T) Rabbit Monoclonal Antibody (CST #12098) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPGAM1 (D3J9T) Rabbit Monoclonal Antibody recognizes endogenous levels of total PGAM1 protein. This antibody may cross react with overexpressed PGAM2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Hamster, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PGAM1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPhosphoglycerate mutase (PGAM1) catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis (1-5). Research studies have shown increased PGAM1 expression in cancer (1-4) and mental disease (5). Specifically, PGAM1 was shown to be phosphorylated at His11 by phosphoenolpyruvate (PEP) in PKM2-expressing cells, suggesting a possible regulatory role for PGAM1 in actively proliferating cells via an alternative glycolytic pathway (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBPG-dependent PGAM 1; epididymis secretory protein Li 35; HEL-S-35; PGAM-B; PGAM1; PGAMA; Phosphoglycerate mutase 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase A, nonmuscle form; Phosphoglycerate mutase isozyme B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Hm Mk\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797565886633,"sku":"12098S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12098s","provider":"Iright","version":"1.0","type":"link"}