{"product_id":"cst-12227t","title":"CST,  12227T, IL-4 (D19A10) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IL4. Validated for Western Blotting,Flow Cytometry (Fixed\/Permeabilized). Available in 2 sizes. Highly specific and rigorously validated in-house, IL-4 (D19A10) Rabbit Monoclonal Antibody (CST #12227) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nFlow Cytometry (Fixed\/Permeabilized): 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIL-4 (D19A10) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-4 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant human IL-4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-4 (IL-4) is a cytokine secreted by activated T cells, basophils, and mast cells (1,2). While it contributes to many immunomodulatory responses, it is mainly recognized as the cytokine responsible for eliciting differentiation of naive T cells into Th2 lineage cells that are defined by their secretion of IL-4, IL-5, and IL-10 (3). In addition, IL-4 contributes to immunoglobulin class switching by inducing the production of IgE from B cells (4,5). IL-4 acts through the IL-4 receptor, leading to tyrosine phosphorylation and activation of the Stat6 transcription factor (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB cell growth factor 1; B cell stimulatory factor 1; B_cell stimulatory factor 1; B-cell stimulatory factor 1; BCGF-1; BCGF1; Binetrakin; BSF-1; BSF1; IL-4; IL4; interleukin 4; interleukin 4 variant 2; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 17\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797567852713,"sku":"12227T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12227t","provider":"Iright","version":"1.0","type":"link"}