{"product_id":"cst-12305s","title":"CST,  12305S, Thap11\/Ronin Antibody","description":"Polyclonal Antibody for studying THAP11. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Thap11\/Ronin Antibody (CST #12305) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThap11\/Ronin Antibody recognizes endogenous levels of total Thap11\/Ronin protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Thap11 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThanatos-associated protein (Thap) proteins are a family of cellular factors that are characterized by an evolutionarily conserved protein motif similar to the DNA-binding domain of P element transposase (1). There are 12 known human Thap proteins that all act as site-specific DNA-binding factors involved in transcriptional regulation, cell proliferation, chromatin modification, and apoptosis (2-4). Human Thap11 has been shown to suppress cell growth through transcriptional suppression of c-Myc (5). The mouse homolog of Thap11, Ronin, has been identified as an essential factor underlying embryogenesis in mouse embryonic stem cells (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCTG-B43a; CTG-B45d; HRIHFB2206; RONIN; THA11; THAP domain containing 11; THAP domain-containing protein 11; THAP11\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 49\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797570048169,"sku":"12305S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12305s","provider":"Iright","version":"1.0","type":"link"}