{"product_id":"cst-12409t","title":"CST,  12409T, SOS1 (D3T7T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SOS1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, SOS1 (D3T7T) Rabbit Monoclonal Antibody (CST #12409) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSOS1 (D3T7T) Rabbit Monoclonal Antibody recognizes endogenous levels of total SOS1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Hamster, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1250 of human SOS1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSon of sevenless (SOS) was first identified in as a guanine nucleotide exchange factor (GEF) for Ras acting downstream of the Sevenless receptor (1). Two closely related homologs of SOS are found in mammalian cells: SOS1 and SOS2 (2). SOS1 consists of histone folds, Dbl (DH) and pleckstrin (PH) homology domains, a Ras exchange motif (REM), and Cdc25 homology and polyproline domains (3). SOS1 binds to GRB2, NCK, and other adaptor proteins, and plays an important role in ERK activation downstream of protein tyrosine kinase receptor (RTK). Research studies have identified mutations in the corresponding SOS1 gene of patients with Noonan syndrome, a developmental disorder characterized by short stature, facial dysmorphia, and congenital heart defects (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; HGF; NS4; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); SOS Ras\/Rac guanine nucleotide exchange factor 1; SOS-1; SOS1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Hm Mk\nSENSITIVITY: Endogenous\nMW (kDa): 152\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797571621033,"sku":"12409T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12409t","provider":"Iright","version":"1.0","type":"link"}