{"product_id":"cst-12436s","title":"CST,  12436S, FIP200 (D10D11) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RB1CC1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, FIP200 (D10D11) Rabbit Monoclonal Antibody (CST #12436) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFIP200 (D10D11) Rabbit Monoclonal Antibody recognizes endogenous levels of total FIP200 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FIP200 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nFIP200 (FAK family kinase-interacting protein of 200 kDa) was identified in a two-hybrid screen with the tyrosine kinase Pyk2 and can inhibit Pyk2 kinase activity as well as related family members (1). FIP200 was later independently identified in a multi-drug resistance screen and named RB1CC1 (RB1-inducible coiled-coil 1) due to its induction by cytotoxic stress and RB1 expression regulation (2). FIP200 function has been linked to apoptosis, cell cycle progression, cell growth, and migration (reviewed in 3). FIP200 has also recently been shown to interact with ULK1 and is required for autophagosome formation (4). FIP200 is part of an ULK1 complex along with Atg13 that is regulated by mTOR and is required for starvation induced autophagy (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n200 kDa FAK family kinase-interacting protein; ATG17; CC1; FAK family kinase-interacting protein of 200 kDa; FIP200; KIAA0203; phosphatase 1, regulatory subunit 131; PPP1R131; RB1 inducible coiled-coil 1; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1; RB1CC1; RBCC1; RBICC\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 200\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797572014249,"sku":"12436S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12436s","provider":"Iright","version":"1.0","type":"link"}