{"product_id":"cst-12457s","title":"CST,  12457S, BRE (D8Q1J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying BRE. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, BRE (D8Q1J) Rabbit Monoclonal Antibody (CST #12457) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBRE (D8Q1J) Rabbit Monoclonal Antibody recognizes endogenous levels of total BRE protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln150 of human BRE protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of the DNA damage response and DNA repair. BRCA1 protein forms at least three distinct complexes (BRCA1 A, B, and C) with other DNA repair proteins, and these interactions are vital for regulation of BRCA1 function. The BRCA1 A complex includes Rap80, BRCC36, Abraxas, MERIT40\/NBA1, and BRE\/BRCC45 and functions in G2\/M phase checkpoint control (reviewed in 1,2). MERIT40 and BRE maintain the stability of both the BRCA1 A complex and the cytoplasmic BRISC complex, which contains BRCC36 and ABRO1 but not BRCA1 (3). Researchers have shown that the expression level of BRE is related to patient survival in breast cancer (4), and it may predict a favorable outcome in acute myeloid leukemia (AML) (5,6). Studies have also shown that BRE is overexpressed in human hepatocellular carcinoma (7) and that overexpression of BRE can cause resistance to apoptotic signaling and promote tumor growth (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBABA2; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); Brain and reproductive organ-expressed protein; BRCA1-A complex subunit BRE; BRCA1\/BRCA2-containing complex subunit 45; BRCA1\/BRCA2-containing complex, subunit 4; BRCC4; BRCC45; BRE; BRISC and BRCA1 A complex member 2; BRISC and BRCA1-A complex member 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 45\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797572669609,"sku":"12457S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12457s","provider":"Iright","version":"1.0","type":"link"}