{"product_id":"cst-12524s","title":"CST,  12524S, CBARA1\/MICU1 (D4P8Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MICU1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CBARA1\/MICU1 (D4P8Q) Rabbit Monoclonal Antibody (CST #12524) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCBARA1\/MICU1 (D4P8Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total CBARA1\/MICU1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys110 of human CBARA1\/MICU1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCBARA1\/MICU1 is a mitochondrial protein associated to the mitochondrial inner membrane that is comprised of two EF hand helix-loop-helix motifs. CBARA1\/MICU1 is involved in mitochondrial calcium entry, metabolic coupling between cytosolic calcium transients, and activation of matrix dehydrogenases (1). Mitochondrial CBARA1\/MICU1 is required to preserve normal mitochondrial calcium concentration below the equilibrium level by interacting with the uniporter pore-forming subunit MCU (2). CBARA1\/MICU1 is important in pancreatic β-cell mitochondrial calcium uptake and sustained insulin secretion (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nara CALC; atopy related autoantigen; Atopy-related autoantigen CALC; CALC; calcium binding atopy-related autoantigen 1; Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1; CBAA1; CBARA1; DKFZp564C246; EFHA3; FLJ12684; MICU1; mitochondrial calcium uptake 1; MPXPS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 47\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797573619881,"sku":"12524S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12524s","provider":"Iright","version":"1.0","type":"link"}