{"product_id":"cst-12661t","title":"CST,  12661T, IL-17RA (D1Y4C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IL17R. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IL-17RA (D1Y4C) Rabbit Monoclonal Antibody (CST #12661) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIL-17RA (D1Y4C) Rabbit Monoclonal Antibody recognizes endogenous levels of total IL-17RA protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant fragment of the human IL-17RA extracellular domain.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE (1). IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells (2). IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides (2). In addition, IL-17A contributes to the pathogenesis of several autoimmune diseases (3). IL-17E promotes Th2 cell responses (4). The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines (1,5,6). IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1 (7). Unlike most cytokines that signal through Jak\/STAT pathways, IL-17 signaling results in NF-κB activation (8). IL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17F (9,10). IL-17RA is broadly expressed with highest expression in hematopoietic cells (11).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCANDF5; CD217; CDw217; hIL-17R; I17RA; IL-17 receptor A; IL-17RA; IL17R; IL17RA; IMD51; interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 120-170\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797576274089,"sku":"12661T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12661t","provider":"Iright","version":"1.0","type":"link"}