{"product_id":"cst-12691t","title":"CST,  12691T, xCT\/SLC7A11 (D2M7A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SLC7A11. Validated for Western Blotting,Immunoprecipitation. Available in 3 sizes. Highly specific and rigorously validated in-house, xCT\/SLC7A11 (D2M7A) Rabbit Monoclonal Antibody (CST #12691) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nxCT\/SLC7A11 (D2M7A) Rabbit Monoclonal Antibody recognizes endogenous levels of total xCT\/SLC7A11 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala224 of human xCT\/SLC7A11 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe X cystine\/glutamate antiporter consists of a light chain subunit (xCT\/SLC7A11) that confers substrate specificity and a glycosylated heavy chain subunit (4F2hc\/SLC3A2) located on the cell surface (1,2). The heterodimeric amino acid transport system X provides selective import of cystine into cells in exchange for glutamate and regulates intracellular glutathione (GSH) levels, essential for cellular protection from oxidative stress (3). Research studies have shown that xCT expression increases in various tumors, including gliomas, and have implicated xCT in GSH-mediated anticancer drug resistance (4,5). Researchers have found that xCT provides neuroprotection by enhancing glutathione export from non-neuronal cells (6). Moreover, investigators identified xCT as the fusion-entry receptor for Kaposi's sarcoma-associated herpesvirus (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\namino acid transport system xc calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; CCBR1; Cystine\/glutamate transporter; SLC7A11; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 35\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797576962217,"sku":"12691T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12691t","provider":"Iright","version":"1.0","type":"link"}