{"product_id":"cst-12796s","title":"CST,  12796S, AFAP1L2\/XB130 (D4A5) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying AFAP1L2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, AFAP1L2\/XB130 (D4A5) Rabbit Monoclonal Antibody (CST #12796) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAFAP1L2\/XB130 (D4A5) Rabbit Monoclonal Antibody recognizes endogenous levels of total AFAP1L2\/XB130 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val391 of human AFAP1L2\/XB130 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe actin-filament associated protein (AFAP) family consists of AFAP1, AFAP1L1, and AFAP1L2\/XB130, a group of structurally similar proteins that play distinct roles in the regulation of cytoskeletal dynamics and signal transduction. Actin filament-associated protein 1-like 2 (AFAP1L2, XB130) is an adaptor protein that regulates signaling downstream of multiple kinases, including Src, Akt, and the thyroid specific kinase RET\/PTC (1-3). Through these pathways, AFAP1L2\/XB130 mediates transcriptional regulation, cell proliferation, motility, and microRNA expression (4,5). Research has shown that AFAP1L2\/XB130 is involved in the proliferation and survival of thyroid tumor cells (6), and may have value in gastric cancer prognosis (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nactin filament associated protein 1 like 2; actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; CTB-1144G6.6; FLJ14564; KIAA1914; XB130\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 130\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797580992681,"sku":"12796S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-12796s","provider":"Iright","version":"1.0","type":"link"}