{"product_id":"cst-13057s","title":"CST,  13057S, DAZL (D2A4) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DAZL. Validated for Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, DAZL (D2A4) Rabbit Monoclonal Antibody (CST #13057) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDAZL (D2A4) Rabbit Monoclonal Antibody recognizes endogenous levels of total DAZL protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe human (Deleted in Azoospermia) gene family contains at least three members that encode RNA-binding proteins with a common RNA-recognition motif (1). An autosomal homolog of DAZ, DAZL (DAZ-like), is specifically expressed in germ cells and is essential for the \u003cb\u003eSpecification\u003c\/b\u003e of the germ cell lineage during embryogenesis and during gametogenesis in adults of both sexes (2,3). DAZL may function by directly recruiting poly(A)-binding proteins (PABPs) in order to activate silent mRNAs during germ cell development (2). Deletions encompassing the Y chromosomal genes are the most common molecularly defined cause of infertility in humans (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDAZ homolog; DAZ-like autosomal; DAZH; DAZL; DAZL1; DAZLA; deleted in azoospermia like; Deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like autosomal; germline specific RNA binding protein; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; SPGYLA; testis secretory sperm-binding protein Li 204a\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 38\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800275341481,"sku":"13057S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13057s","provider":"Iright","version":"1.0","type":"link"}