{"product_id":"cst-13062s","title":"CST,  13062S, AGR2 (D9V2F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying AGR2. Validated for WB,IHC,IF,F. Available in 2 sizes. Highly specific and rigorously validated in-house, AGR2 (D9V2F) Rabbit Monoclonal Antibody (CST #13062) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:800\nImmunofluorescence (Immunocytochemistry): 1:100\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 86533 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Immunocytochemistry), Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAGR2 (D9V2F) Rabbit Monoclonal Antibody recognizes endogenous levels of total AGR2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala29 of human AGR2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAnterior gradient homolog 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family of proteins and a homolog of the cement gland protein (1). In normal human tissues, AGR2 is expressed most abundantly in intestinal cells. Research studies have found AGR2 is overexpressed in a number of adenocarcinomas, including those derived from breast, pancreas, ovary, prostate and esophagus (2-4). and studies have shown that AGR2 positively regulates cell growth and division, while its overexpression can promote cell transformation (5,6). The latter functions of AGR2 were shown to involve YAP1-mediated up-regulation of amphiregulin expression, implicating AGR2 in both the EGF and Hippo kinase signaling pathways (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAG-2; AG2; AGR2; anterior gradient 2 homolog; anterior gradient 2, protein disulphide isomerase family member; anterior gradient homolog 2; anterior gradient homolog 2 (Xenopus laevis); Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; GOB-4; hAG-2; HEL-S-116; HPC8; PDIA17; protein disulfide isomerase family A, member 17; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; XAG-2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797586104489,"sku":"13062S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13062s","provider":"Iright","version":"1.0","type":"link"}