{"product_id":"cst-13101s","title":"CST,  13101S, NVP-BEZ235","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNVP-BEZ235 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.065 ml DMF and warm to 75°C for 5 minutes. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 5 nM-500 nM for 2-24 hr.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nNVP-BEZ235 is a selective and potent dual inhibitor of PI3 kinase and mTOR Ser\/Thr protein kinase. Research studies show that NVP-BEZ235 reversibly inhibits the catalytic activity of these kinases by competing with ATP at the ATP-binding site (1,2). Studies demonstrate that NVP-BEZ235 has anti-proliferative characteristics and induces cell cycle arrest during G \/G phase through inhibition of CDK4 and cyclin D3 (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBEZ235; CDK4; cyclin D3; inhibitor; mTOR; NVP; PI3K","brand":"CST","offers":[{"title":"Default Title","offer_id":46800691921065,"sku":"13101S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13101s","provider":"Iright","version":"1.0","type":"link"}