{"product_id":"cst-13123s","title":"CST,  13123S, PFKFB3 (D7H4Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PFKFB3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PFKFB3 (D7H4Q) Rabbit Monoclonal Antibody (CST #13123) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPFKFB3 (D7H4Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total PFKFB3 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu456 of human PFKFB3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe bifunctional 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase (PFK\/FBPase or PFKFB) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate and regulates its steady-state level (1,2). Fructose 2,6-bisphosphate activates phosphofructokinase, a rate-limiting enzyme in glycolysis, by allosteric regulation (1,2). Four different PFKFB isoforms (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified (1,2). One of them, PFKFB3\/iPFK-2, was shown to be inducible by hypoxia leading to increased glycolysis under hypoxic conditions (2). Research studies have shown that PFKFB3\/iPFK-2 is also highly expressed in some types of human cancer (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase\/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase\/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase\/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase 3; 6PF-2-K\/Fru-2,6-P2ase 3; 6PF-2-K\/Fru-2,6-P2ase brain\/placenta-type isozyme; F263; FLJ37326; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase\/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase; iPFK-2; IPFK2; PFK\/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY-REN-56\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797587873961,"sku":"13123S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13123s","provider":"Iright","version":"1.0","type":"link"}