CST, 13144S, Neurogenin 2 (D2R3D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying neurogenin 2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Neurogenin 2 (D2R3D) Rabbit Monoclonal Antibody (CST #13144) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Neurogenin 2 (D2R3D) Rabbit Monoclonal Antibody recognizes endogenous levels of total neurogenin 2 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human neurogenin 2 protein. Background Neurogenin 2 (Ngn2, NeuroG2) is a proneural, basic helix-loop-helix transcription (bHLH) factor and member of the neurogenin family that includes neurogenin 1 and neurogenin 3 (1). Neurogenin 2 is expressed in neuronal progenitor cells, is required for generation of glutamatergic neurons and is commonly used as a marker of neuronal differentiation (2,3). Neurogenin 2 upregulates a number of targets including the bHLH transcription factor NeuroD (4). Phosphorylation of Ngn2 at Tyr241 controls migration and dendritic morphology of cortical neurons (5). Alternate Names ATOH4; BHLHA8; Class A basic helix-loop-helix protein 8; Math4A; MGC46562; NEUROG2; neurogenin 2; Neurogenin-2; NGN-2; NGN2; Protein atonal homolog 4 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 35 Source/Isotype: Rabbit IgG