{"product_id":"cst-13457s","title":"CST,  13457S, Lmx1B (D1E2) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LMX1B. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Lmx1B (D1E2) Rabbit Monoclonal Antibody (CST #13457) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLmx1B (D1E2) Rabbit Monoclonal Antibody recognizes transfected levels of total Lmx1B protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Lmx1B protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLIM homeobox transcription factor 1 β (Lmx1B) is a member of an evolutionarily conserved family of transcription factors that regulate developmental pattern formation in both vertebrates and invertebrates (1). Numerous developmental studies show that Lmx1B is required for vertebrate dorsoventral limb patterning, as well as normal glomerular basement membrane development and typical differentiation of central serotonergic neurons (2,3). Mutations in the corresponding gene have been associated with nail-patella syndrome (NPS), an autosomal dominant disorder characterized by dysplasia of fingernails, skeletal anomalies and, frequently, renal disease (2). Abnormal developmental disorders such as developmental glaucoma and idiopathic Parkinson's disease have also been associated with Lmx1B function (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nLIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; LIM homeobox transcription factor 1, beta; LIM\/homeobox protein 1.2; LIM\/homeobox protein LMX1B; LMX-1.2; LMX1.2; LMX1B; MGC138325; MGC142051; NPS1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Transfected Only\nMW (kDa): 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797594919081,"sku":"13457S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13457s","provider":"Iright","version":"1.0","type":"link"}