CST, 13457T, Lmx1B (D1E2) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LMX1B. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Lmx1B (D1E2) Rabbit Monoclonal Antibody (CST #13457) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity Lmx1B (D1E2) Rabbit Monoclonal Antibody recognizes transfected levels of total Lmx1B protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Lmx1B protein. Background LIM homeobox transcription factor 1 β (Lmx1B) is a member of an evolutionarily conserved family of transcription factors that regulate developmental pattern formation in both vertebrates and invertebrates (1). Numerous developmental studies show that Lmx1B is required for vertebrate dorsoventral limb patterning, as well as normal glomerular basement membrane development and typical differentiation of central serotonergic neurons (2,3). Mutations in the corresponding gene have been associated with nail-patella syndrome (NPS), an autosomal dominant disorder characterized by dysplasia of fingernails, skeletal anomalies and, frequently, renal disease (2). Abnormal developmental disorders such as developmental glaucoma and idiopathic Parkinson's disease have also been associated with Lmx1B function (4,5). Alternate Names LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; LIM homeobox transcription factor 1, beta; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX-1.2; LMX1.2; LMX1B; MGC138325; MGC142051; NPS1 Specification REACTIVITY: H SENSITIVITY: Transfected Only MW (kDa): 50 Source/Isotype: Rabbit IgG