CST, 13519T, LXR-beta (D6M9D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying LXR-beta. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LXR-beta (D6M9D) Rabbit Monoclonal Antibody (CST #13519) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity LXR-beta (D6M9D) Rabbit Monoclonal Antibody recognizes endogenous levels of total LXR-β protein. Species Reactivity: Human, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LXR-β protein. Background Liver X receptors LXR-α and LXR-β are nuclear hormone receptor superfamily members responsible for regulating expression of target genes that control cholesterol transport and metabolism (1). When bound by the oxidized derivatives of cholesterol (oxysterols), activated LXR receptors function as sterol sensors to regulate transcription of the genes involved in the cholesterol homeostasis (1,2). The LXR-α protein is expressed at high levels in rat liver, kidney, intestine, adipose, and spleen; LXR-β is more ubiquitously expressed within rat tissues (1,3). Research studies indicate that glucose binds and upregulates the transcriptional activity of LXR-α and LXR-β (4). LXR-α and LXR-β are putative glucose sensors that integrate glucose metabolism and fatty acid biosynthesis in the liver (4). Additional studies show that female mice deficient in LXR-β develop gallbladder cancer (5). In addition, LXR-β plays a role in protecting dopaminergic neurons in a Parkinson's disease model (6). Alternate Names liver X nuclear receptor beta; Liver X receptor beta; liver X receptor-beta; LX receptor beta; LXR-b; LXR-beta; LXRB; NER; NER-I; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; UNR Specification REACTIVITY: H R SENSITIVITY: Endogenous MW (kDa): 63 Source/Isotype: Rabbit IgG