CST, 13544S, PVR/CD155 (D3G7H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying PVR. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PVR/CD155 (D3G7H) Rabbit Monoclonal Antibody (CST #13544) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity PVR/CD155 (D3G7H) Rabbit Monoclonal Antibody recognizes endogenous levels of total PVR (CD155) protein. Based on the protein sequence, this antibody is expected to recognize the α, β, γ, and δ isoforms of PVR (CD155) protein. Species Reactivity: Human, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg172 of human PVR (CD155) protein. Background Poliovirus receptor (PVR), also known as CD155 and nectin-like 5 (Necl-5), is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR expression may play a role in the invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6). Alternate Names CD155; FLJ25946; HVED; NECL-5; NECL5; nectin-like 5; Nectin-like protein 5; Poliovirus receptor; PVR; PVR cell adhesion molecule; PVS; TAGE4 Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 60-80 glycosylated 45-50 nonglycosylated Source/Isotype: Rabbit IgG