{"product_id":"cst-13626s","title":"CST,  13626S, DAG Lipase alpha (D3G8H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DAGLALPHA. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, DAG Lipase alpha (D3G8H) Rabbit Monoclonal Antibody (CST #13626) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDAG Lipase alpha (D3G8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total DAG lipase α protein. This antibody is not predicted to cross-react with DAG lipase β based on sequence homology of the antigen.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser791 of human DAG lipase α protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDiacylglycerol (DAG) lipases comprise two enzymes called DAG lipase α and β, which are the products of two related genes (1). DAG lipases are transmembrane proteins composed of a short amino-terminal intracellular domain, four transmembrane domains, and a large carboxy-terminal cytoplasmic domain containing the active site. These enzymes are responsible for the biosynthesis of 2-acylglycerol from diacylglycerol in a calcium-dependent manner (1). One of the major endocannabinoid ligands that activate cannabinoid receptors, 2-arachidonyl glycerol (2-AG), is produced by DAG lipases (2). Research studies suggest that DAG lipase α is the isoform primarily responsible for the central production of 2-AG (3). DAG lipase β has been implicated in studies of 2-AG production at the periphery in specific cell types and pathophysiological contexts, such as in hepatic stellate cells during alcohol induced fatty liver (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC11orf11; DAGL-alpha; DAGL(ALPHA); DAGLA; DAGLALPHA; DGL-alpha; DGLA; diacylglycerol lipase alpha; Diacylglycerol lipase-alpha; diacylglycerol lipase, alpha; KIAA0659; Neural stem cell-derived dendrite regulator; NSDDR; Sn1-specific diacylglycerol lipase alpha\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 115\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797598195881,"sku":"13626S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13626s","provider":"Iright","version":"1.0","type":"link"}