{"product_id":"cst-13640s","title":"CST,  13640S, VAMP3 Antibody","description":"Polyclonal Antibody for studying VAMP3. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, VAMP3 Antibody (CST #13640) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nVAMP3 Antibody recognizes endogenous levels of total VAMP3 protein. This antibody does not cross-react with VAMP1 or VAMP2 proteins.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human VAMP3 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nProteins in the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex are integral membrane proteins involved in vesicle transport and membrane fusion by pairing of vesicular SNAREs (v-SNAREs) with cognate target SNAREs (t-SNAREs) (reviewed in 1,2). Vesicle-associated membrane protein 3 (VAMP3), also known as cellubrevin, has a broad tissue distribution and localizes to endosomal compartments (3). VAMP3 interacts with the t-SNAREs syntaxin1, syntaxin4, SNAP23, and SNAP25 (4,5). Research studies indicate that VAMP3 is involved in transferrin receptor recycling to the plasma membrane (6) and T cell receptor recycling to immunological synapses (7). Inhibition of VAMP3 with tetanus toxin impairs membrane trafficking during cell migration (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCEB; Cellubrevin; SYB3; Synaptobrevin-3; VAMP-3; VAMP3; vesicle associated membrane protein 3; Vesicle-associated membrane protein 3; vesicle-associated membrane protein 3 (cellubrevin)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 13\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797598326953,"sku":"13640S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13640s","provider":"Iright","version":"1.0","type":"link"}