CST, 13706S, MCUR1 Antibody

Polyclonal Antibody for studying MCUR1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, MCUR1 Antibody (CST #13706) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MCUR1 Antibody recognizes endogenous levels of total MCUR1 protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala305 of human MCUR1 protein. Antibodies are purified by protein A and peptide affinity chromatography. Background Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) is a mitochondrial inner membrane protein involved in the uptake of calcium. This multi-pass protein contains two transmembrane domains with both amino- and carboxy-termini projecting into the same mitochondrial intermembrane space (1). Research studies indicate that reduction in MCUR1 activity results in decreased mitochondrial Ca uptake, while overexpression of MCUR1 results in increased mitochondrial calcium levels (1). MCUR1 protein directly interacts with mitochondrial calcium uniporter (MCU) and plays an essential role in the regulation of calcium uptake and maintenance of mitochondrial calcium homeostasis (1). Regulation of MCU by MCUR1 may be critical for a variety of cellular functions, including signal transduction, bioenergetics, and cell death and survival (2). Alternate Names C6orf79; CC90A; CCDC90A; coiled-coil domain containing 90A; Coiled-coil domain-containing protein 90A, mitochondrial; epididymis secretory sperm binding protein; FLJ20958; FMP32; MCU regulator 1; MCUR1; Mitochondrial calcium uniporter regulator 1 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 23 SOURCE: Rabbit