{"product_id":"cst-13824s","title":"CST,  13824S, CDIP Antibody","description":"Polyclonal Antibody for studying CDIP. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, CDIP Antibody (CST #13824) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCDIP Antibody recognizes endogenous levels of total CDIP protein. This antibody may detect proteins of unknown origin at 35 and 70 kDa in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CDIP protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCell Death Involved p53-Target (CDIP) is a pro-apoptotic protein induced by genotoxic stress in a p53-dependent manner (1). Indeed, CDIP is a direct target of p53. Inhibition of CDIP impairs p53-mediated apoptosis. Induction of apoptosis by CDIP requires caspase-8 suggesting involvement in the extrinsic apoptotic pathway. CDIP also promotes increased expression of TNF-α capable of triggering apoptosis. Furthermore, expression of CDIP correlates with increased sensitivity of TNF-α-induced apoptosis (2). These studies suggest that CDIP may serve as a marker for apoptotic sensitivity.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n5730403B10Rik; C16orf5; CDIP; CDIP1; cell death inducing p53 target 1; cell death inducing protein; Cell death involved p53-target; Cell death-inducing p53-target protein 1; Cell death-inducing protein; chromosome 16 open reading frame 5; I1; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; LITAF-like protein; LITAFL; LITFL; Transmembrane protein I1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 24,26\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797601145001,"sku":"13824S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13824s","provider":"Iright","version":"1.0","type":"link"}