{"product_id":"cst-13911v3","title":"CST,  13911V3, PathScan® Phospho-S6 Ribosomal Protein (Ser240\/244) Sandwich ELISA Kit","description":"ELISA Kit for studying S6 Ribosomal Protein (Ser240\/Ser244) phosphate in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPathScan\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eBackground\u003c\/b\u003e\nOne way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation (1,2). Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions (2). These particular mRNA transcripts (5'TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation (2,3). Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of S6 protein (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n40S ribosomal protein S6; Phosphoprotein NP33; ribosomal protein S6; RPS6; RS6; S6; S6 ribosomal protein; Small ribosomal subunit protein eS6\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M","brand":"CST","offers":[{"title":"Default Title","offer_id":46800577560745,"sku":"13911V3","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-13911v3","provider":"Iright","version":"1.0","type":"link"}