{"product_id":"cst-14065s","title":"CST,  14065S, Lyric\/Metadherin (D5Y8R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LYRIC. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Lyric\/Metadherin (D5Y8R) Rabbit Monoclonal Antibody (CST #14065) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:150\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLyric\/Metadherin (D5Y8R) Rabbit Monoclonal Antibody recognizes endogenous levels of total lyric\/metadherin protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala140 of human lyric\/metadherin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLyric\/AEG-1 (Astrocyte Elevated Gene 1)\/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium (1). Differential subcellular localization and overexpression of Lyric\/AEG-1\/MTDH has been seen in multiple human cancers. Lyric\/AEG-1\/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis\/survival, and its alteration in cancer is associated with poor prognosis (reviewed in 2). In breast cancer, increased Lyric\/AEG-1\/MTDH may confer increased chemoresistance as well as metastasis (3,4). Lyric\/AEG-1\/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) (5) and glioblastoma multiforme (GBM) (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n3D3; 3D3\/LYRIC; AEG-1; AEG1; astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC\/3D3; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 65,75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797604028585,"sku":"14065S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14065s","provider":"Iright","version":"1.0","type":"link"}