{"product_id":"cst-14098s","title":"CST,  14098S, MORF4L1\/MRG15 (D2Y4J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MORF4L1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MORF4L1\/MRG15 (D2Y4J) Rabbit Monoclonal Antibody (CST #14098) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMORF4L1\/MRG15 (D2Y4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total MORF4L1\/MRG15 protein. This antibody may recognize a 90 kDa protein of unknown origin in some cells.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala237 of human MORF4L1\/MRG15 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMortality factor 4-like protein 1 (MORF4L1\/MRG15) is a chromo domain-containing protein that is part of several histone modifying complexes, including the Tip60 histone acetyltransferase (HAT) complex, histone deacetylase (HDAC) complexes, and the JARID1A and JARID1B histone demethylase complexes (1-6). MORF4L1\/MRG15 recognizes di- or trimethylated Lys36 of histone H3 through its chromo domain. This interaction recruits and anchors MORF4L1\/MRG15-associated chromatin modifying complexes to target genes for transcriptional regulation (7,8). MORF4L1\/MRG15 plays a role in DNA repair as part of the Tip60 HAT complex (9,10). MORF4L1\/MRG15 regulates alternative splicing during co-transcriptional splicing of mRNA as a part of the JARID1A complex (11). MORF4L1\/MRG15 recruitment of the JARID1B complex to embryonic stem cell renewal-associated genes is important for repression of cryptic transcription and maintenance of proper transcriptional elongation (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEaf3; Esa1p-associated factor 3 homolog; FWP006; HsT17725; MEAF3; MGC10631; MO4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; MRG15; Protein MSL3-1; S863-6; Transcription factor-like protein MRG15\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797604520105,"sku":"14098S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14098s","provider":"Iright","version":"1.0","type":"link"}